Antihistamines (H1 & H2)
H1 and H2 receptor blockers used for allergy, MCAS, chronic urticaria, and related histamine-driven conditions — compounded dye-free for sensitive patients.
About Antihistamines
Antihistamines block histamine at H1 receptors (cetirizine, hydroxyzine, diphenhydramine, azelastine) or H2 receptors (famotidine). Cyproheptadine is a first-generation H1 blocker with additional antiserotonergic activity. In MCAS and CIRS protocols, H1 and H2 antihistamines are typically layered together and often combined with mast cell stabilizers. Compounding is frequently requested because many MCAS patients react to commercial tablet coatings, dyes, and fillers. Licensed 503A compounding pharmacies can prepare these drugs in dye-free, filler-minimized capsules, liquids, and transdermal creams.
Medications in This Class
Click any medication to compare prices from licensed U.S. compounding pharmacies.
Cetirizine
Cetirizine is a second-generation H1 antihistamine used for allergies, chronic hives, and mast cell activation syndrome ...
Compare prices →Levocetirizine
Levocetirizine is the active enantiomer of cetirizine — a second-generation H1 antihistamine frequently layered into MCA...
Compare prices →Loratadine
Loratadine is a second-generation H1 antihistamine used for allergic rhinitis, chronic urticaria, and mast cell activati...
Compare prices →Desloratadine
Desloratadine is the active metabolite of loratadine — a second-generation H1 antihistamine with slightly higher potency...
Compare prices →Fexofenadine
Fexofenadine is a non-sedating second-generation H1 antihistamine used for allergic rhinitis, chronic urticaria, and MCA...
Compare prices →Hydroxyzine
Hydroxyzine is a first-generation H1 antihistamine prescribed for anxiety, allergies, and pruritus. Compounded dye-free ...
Compare prices →Diphenhydramine
Diphenhydramine (Benadryl) is a first-generation H1 antihistamine available in compounded formulations including dye-fre...
Compare prices →Chlorpheniramine
Chlorpheniramine is a first-generation H1 antihistamine used for allergies, cold symptoms, and pediatric dermatologic re...
Compare prices →Promethazine
Promethazine is a first-generation H1 antihistamine with antiemetic and sedating properties, used for nausea, motion sic...
Compare prices →Meclizine
Meclizine is a first-generation H1 antihistamine used for vertigo, motion sickness, and vestibular migraine. Compounded ...
Compare prices →Doxepin
Doxepin is a tricyclic with exceptionally potent H1 and H2 blockade — on a per-mg basis, roughly 1,000x more antihistami...
Compare prices →Azelastine
Azelastine is a second-generation H1 antihistamine primarily used as a nasal spray and eye drops for allergic rhinitis a...
Compare prices →Olopatadine
Olopatadine is a dual-action H1 antihistamine and mast cell stabilizer available as ophthalmic drops and nasal sprays fo...
Compare prices →Cyproheptadine
Cyproheptadine is a first-generation H1 antihistamine with additional antiserotonergic properties. It is commonly compou...
Compare prices →Famotidine
Famotidine is an H2 histamine blocker commonly used for acid reflux, peptic ulcers, and as part of mast cell activation ...
Compare prices →Cimetidine
Cimetidine is an H2 histamine blocker with additional immune-modulating properties that make it a distinct option within...
Compare prices →Nizatidine
Nizatidine is an H2 histamine blocker used as an alternative to famotidine and cimetidine for GERD, peptic ulcers, and M...
Compare prices →Conditions Treated with Antihistamines
Compare Prices for Antihistamines
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