Compounded Enclomiphene

The most common indication is secondary hypogonadism in men — confirmed low testosterone with low or inappropriately normal LH/FSH — where the prescriber wants to raise endogenous testosterone without suppressing fertility. Enclomiphene stimulates the hypothalamus to release GnRH, which drives LH/FSH production and, in turn, testicular testosterone synthesis.

It's also prescribed as a TRT alternative for men who want to preserve fertility, as an adjunct to TRT to maintain testicular size and function, and as part of post-cycle therapy (PCT) to restart natural testosterone production after exogenous testosterone use. Dosing is typically 12.5–25 mg daily, with lab monitoring of testosterone, LH, FSH, and estradiol every 3 months.

Commercial clomiphene citrate (Clomid) is a racemic mixture — approximately 62% enclomiphene (trans) and 38% zuclomiphene (cis). The enclomiphene fraction is responsible for the testosterone-raising effect; the zuclomiphene fraction is a longer-acting estrogen agonist that some patients tolerate poorly (mood changes, visual disturbances, elevated estradiol).

Compounded enclomiphene is the pure trans-isomer — same testosterone-raising effect without the cis-isomer side effects. It's particularly preferred by clinicians whose patients have previously had mood or estrogenic side effects on Clomid. Clomid is FDA-approved for female infertility; enclomiphene monotherapy is not FDA-approved and is prescribed off-label for male secondary hypogonadism.

Compounding pharmacies typically prepare enclomiphene as oral capsules at custom strengths. The most common strengths are 6.25 mg, 12.5 mg, and 25 mg. Typical dosing for male secondary hypogonadism is 12.5 mg daily, titrated up to 25 mg daily if testosterone response is inadequate after 6 weeks.

Protocols vary — some clinicians use alternating-day dosing (25 mg every other day) or 5-days-on/2-days-off patterns to minimize cumulative side effects. Lab monitoring typically includes total and free testosterone, LH, FSH, estradiol, SHBG, and CBC every 3 months during titration.

Compounded enclomiphene capsules typically run $50–$120 for a 30-day supply at standard 12.5 mg or 25 mg daily dosing. Pricing varies by strength and quantity — a 90-day supply typically costs 2.5–3× the 30-day supply.

Generic clomiphene (not enclomiphene) is often dramatically cheaper but delivers the racemic mixture with more side effects. Clinicians who specifically prescribe enclomiphene have weighed this tradeoff for the individual patient. Comparing quotes from multiple pharmacies typically saves 20–40%.

Prices vary by dosage, formulation, quantity, and pharmacy. The range above reflects listings currently tracked by Compounding Finder and is not a guaranteed quote. Submit a request below to get a personalized quote for your specific needs.

Compounded medication prices vary significantly between pharmacies — sometimes by 300% or more for the exact same drug, strength, and formulation. Factors that affect pricing include the pharmacy’s location, their ingredient sourcing, and compounding volume.

By comparing quotes from multiple licensed pharmacies, you can find the best combination of price, quality, and convenience without spending hours making phone calls.

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