Compounded Progesterone
Compare quotes for compounded Progesterone, see whether a prescription is needed, what affects price, how fast quotes come back, and what happens after you submit.
About Progesterone
Compounded progesterone is the bioidentical form of progesterone used in hormone replacement therapy (HRT), perimenopause symptom management, luteal phase support, and progesterone deficiency. Compounding pharmacies prepare progesterone in oral capsules at custom strengths, sublingual troches, transdermal creams, and vaginal suppositories — offering alternatives to commercial Prometrium 100mg/200mg capsules or the synthetic progestins (medroxyprogesterone, norethindrone) in combined HRT products. Compounded progesterone is often paired with compounded estradiol in bioidentical HRT protocols.
When compounded progesterone is prescribed
The most common indications are menopausal HRT (typically paired with estradiol to protect the endometrium in women with a uterus), perimenopausal symptom management (sleep disruption, anxiety, mood changes), and luteal phase support in fertility cycles.
Some clinicians also prescribe progesterone for PCOS, cyclic breast pain, and as a standalone therapy for perimenopausal sleep disturbance even when full HRT isn't indicated. Prometrium 100mg and 200mg capsules cover many patients; compounding is appropriate when custom strengths, alternative delivery, or FDA-unapproved formulations are needed.
Compounded progesterone vs synthetic progestins
The bioidentical progesterone molecule — whether in Prometrium or a compounded preparation — is structurally identical to the progesterone the ovaries produce. Synthetic progestins (medroxyprogesterone in Provera and Prempro, norethindrone in various oral contraceptives, drospirenone) are structurally different molecules with different side-effect profiles.
Clinical evidence suggests bioidentical progesterone has lower risk of breast cancer and cardiovascular events than synthetic progestins in menopausal HRT. For that reason, many HRT clinicians preferentially prescribe bioidentical progesterone (either Prometrium or compounded) over combined HRT products containing synthetic progestins.
Available formulations and dosing
Compounding pharmacies most commonly prepare progesterone as: oral micronized capsules (50–300 mg at custom strengths); sublingual troches (25–200 mg); transdermal creams (20–200 mg/mL); and vaginal suppositories (100–400 mg for luteal support or localized use).
Typical menopausal HRT dosing is 100–200 mg at bedtime (often delivering a mild sedating effect that helps with sleep). Luteal support in fertility cycles uses 200–400 mg vaginal or 400–800 mg oral. Perimenopause sleep protocols typically use 100 mg oral at bedtime. Your prescriber sets the dose.
Typical compounded progesterone pricing
Compounded oral capsules typically run $30–$75 for a 30- or 90-day supply at standard doses. Transdermal creams are $35–$85 per 30-day supply. Sublingual troches run $40–$90 per 30-day supply. Vaginal suppositories are typically $50–$120 per 30-day supply.
Prometrium (commercial) at 100mg or 200mg is often comparable to or cheaper than compounded oral progesterone at those strengths after insurance. If your dose is non-standard (150mg, 125mg, etc.) or your prescriber wants a non-oral delivery, compounding becomes the practical choice.
Key Questions Before You Request Quotes
Can I get Progesterone compounded?
Possibly. A licensed prescriber has to decide whether Progesterone is appropriate, and a licensed compounding pharmacy has to confirm it can legally prepare the requested strength, form, and quantity.
Is a prescription needed?
Yes. Patient-specific 503A compounding is based on a valid prescription order or prescriber notation for an identified patient.
What affects price?
Strength, dosage form, quantity, ingredient sourcing, sterile versus non-sterile preparation, shipping requirements, and each pharmacy's workflow can all change the final quote.
How fast can I get quotes?
For routable requests, Compounding Finder typically returns quote options by email within 1-2 business days after you submit the request details.
What happens after I submit?
We review the request, route it to eligible licensed pharmacies, collect available options, and email you the quoted choices. You decide whether to move forward with a pharmacy.
Source notes: FDA explains that compounded drugs are not FDA-approved finished products and describes 503A compounding around patient-specific prescriptions. See Compounding and the FDA and Section 503A.
Typical Progesterone Pricing
Prices vary by dosage, formulation, quantity, and pharmacy. The range above reflects listings currently tracked by Compounding Finder and is not a guaranteed quote. Submit a request below to get a personalized quote for your specific needs.
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Progesterone by State
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Why Compare Progesterone Prices?
Compounded medication prices vary significantly between pharmacies — sometimes by 300% or more for the exact same drug, strength, and formulation. Factors that affect pricing include the pharmacy’s location, their ingredient sourcing, and compounding volume.
By comparing quotes from multiple licensed pharmacies, you can find the best combination of price, quality, and convenience without spending hours making phone calls.
Frequently Asked Questions
Is compounded progesterone different from Prometrium?
The active ingredient — bioidentical micronized progesterone — is identical. Prometrium is FDA-approved at fixed 100 mg and 200 mg strengths in oral capsules. Compounded progesterone can be prepared at any custom strength and in alternative forms (troches, creams, vaginal suppositories) that Prometrium doesn't offer. For standard oral HRT at 100 mg or 200 mg, Prometrium is often the economical choice; compounding adds value for non-standard doses or delivery forms.
Is bioidentical progesterone safer than synthetic progestins?
Clinical evidence suggests bioidentical progesterone — whether Prometrium or compounded — has a lower risk of breast cancer and cardiovascular events than synthetic progestins (medroxyprogesterone, norethindrone, drospirenone) when used in menopausal HRT. For this reason, many HRT clinicians preferentially prescribe bioidentical progesterone over combined HRT products containing synthetic progestins.
Can I use compounded progesterone for perimenopause sleep issues?
Many clinicians prescribe 100 mg oral bioidentical progesterone at bedtime for perimenopausal sleep disturbance — progesterone has a mild sedating effect through its metabolites that can help with sleep independently of its endocrine effects. Both Prometrium and compounded progesterone work for this indication. Your prescriber will decide whether it's appropriate for your situation.
How much does compounded progesterone cost?
Compounded oral capsules typically run $30–$75 for a 30- or 90-day supply. Transdermal creams are $35–$85 per 30-day supply. Vaginal suppositories run $50–$120 per 30-day supply. Comparing quotes before filling typically saves 20–40%. For standard 100mg or 200mg oral doses, Prometrium is sometimes the economical alternative.
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